Results
| PMID | 15893866 |
| Gene Name | CCL2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 55 |
| Population details | 55 (18 women with endometriosis, 16 women with uterine leiomyoma, 5 unexplained infertility, 16 fertile women ) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis, Infertility |
|
Eur J Obstet Gynecol Reprod Biol. 2005 Oct 1;122(2):199-205. Gmyrek, Grzegorz B| Sozanski, Rafal| Jerzak, Malgorzata| Chrobak, Agnieszka| Wickiewicz, Dorota| Skupnik, Alicja| Sieradzka, Urszula| Fortuna, Wojciech| Gabrys, Marian| Chelmonska-Soyta, Anna Laboratory of Reproductive Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, Wroclaw, Poland. gregoire@hot.pl OBJECTIVE: To test whether serum monocyte chemotactic protein-1 (MCP-1) chemokine levels correlate with endometriosis in infertile women. STUDY DESIGN: A group of women with endometriosis (n = 18, infertile) was compared with patients with uterine leiomyoma (n = 16, fertile), unexplained infertility (n = 5, infertile), and healthy women (n = 16, fertile). MCP-1 expression levels were evaluated by ELISA assay. The data obtained were statistically analyzed using the Mann-Whitney test. P-Values <0.05 were considered as significant. RESULTS: MCP-1 concentrations (median; range of values) in serum were as follows: women with endometriosis (221; 101-635 pg/ml), women with unexplained infertility (167, 114-234 pg/ml), women with uterine leiomyoma (137; 88-200 pg/ml), and healthy donors (123; 98-194 pg/ml). Significant differences were observed in the women with endometriosis compared with those with uterine leiomyoma (p = 0.02) and healthy donors (p = 0.002). Among the women with endometriosis, the level of significance in MCP-1 level at rAFS stages III-IV was higher than that at rAFS stages I-II compared with healthy donors and women with leiomyoma (p = 0.002 and p = 0.02, respectively). CONCLUSIONS: These data show that an increased level of MCP-1 can characterize infertile women with endometriosis. However, further studies are needed to be able to determine whether increased MCP-1 chemokine expression can be related to infertility or is a result of endometriosis progress. Mesh Terms: Adult| Biomarkers/blood| Chemokine CCL2/*blood| Endometriosis/*blood| Enzyme-Linked Immunosorbent Assay| Female| Humans| Infertility, Female/*blood| Leiomyoma/blood| Uterine Neoplasms/blood|DA 2006/01/25 09:00 |
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